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Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

《医学前沿（英文）》 2021年 第15卷 第1期   页码 101-107 doi: 10.1007/s11684-020-0752-2

摘要： Primary hypothyroidism commonly occurs after radiotherapy (RT), and coincides with increased circulating thyroid-stimulating hormone (TSH) levels. We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma (HL) in a prospective cohort study. From 1998 to 2001, a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL, scheduled for craniospinal irradiation and mediastinum/neck radiotherapy, respectively, underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of craniospinal iiradiation. From 14 days before and up to the end of radiotherapy, patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3 μIU/mL. During follow-up, blood tests and ultrasound were repeated; primary hypothyroidism was considered an increased TSH level greater than normal range. Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels ˂ 0.3 μIU/mL and well matched for other variables. Twenty years on, hypothyroidism-free survival rates differed significantly, being 60%±15% and 15.6%±8.2% in TSH-suppressed vs. not-TSH suppressed patients, respectively ( =0.001). These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae, but it should be confirmed in a larger cohort.

关键词： iatrogenic primary hypothyroidism     late effects of radiotherapy     long-term follow-up     medulloblastoma     Hodgkin lymphoma    

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Artificial intelligence in radiotherapy: a technological review

Ke Sheng

《医学前沿（英文）》 2020年 第14卷 第4期   页码 431-449 doi: 10.1007/s11684-020-0761-1

摘要： Radiation therapy (RT) is widely used to treat cancer. Technological advances in RT have occurred in the past 30 years. These advances, such as three-dimensional image guidance, intensity modulation, and robotics, created challenges and opportunities for the next breakthrough, in which artificial intelligence (AI) will possibly play important roles. AI will replace certain repetitive and labor-intensive tasks and improve the accuracy and consistency of others, particularly those with increased complexity because of technological advances. The improvement in efficiency and consistency is important to manage the increasing cancer patient burden to the society. Furthermore, AI may provide new functionalities that facilitate satisfactory RT. The functionalities include superior images for real-time intervention and adaptive and personalized RT. AI may effectively synthesize and analyze big data for such purposes. This review describes the RT workflow and identifies areas, including imaging, treatment planning, quality assurance, and outcome prediction, that benefit from AI. This review primarily focuses on deep-learning techniques, although conventional machine-learning techniques are also mentioned.

关键词： artificial intelligence     radiation therapy     medical imaging     treatment planning     quality assurance     outcome prediction    

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OVEREXPRESSION OF PTRLEA7, A LATE EMBRYOGENESIS ABUNDANT FAMILY GENE FROM PONCIRUS TRIFOLIATA, CONFERS

《农业科学与工程前沿（英文）》 2021年 第8卷 第2期

摘要：

Late embryogenesis abundant (LEA) genes encode highly hydrophilic proteins that are essential in abiotic stress responses. However, most LEA genes in higher plants have not yet been investigated. This study identified an LEA family gene (PtrLEA7) from Poncirus trifoliata and studied its function in drought tolerance. The full-length coding sequence of PtrLEA7 was 420 bp encoding a protein of 139 amino acids. Phylogenetic analysis shows that PtrLEA7 protein belongs to the LEA_4 subfamily. Expression profiling by qPCR found that PtrLEA7 was strongly induced by dehydration, cold and ABA treatments, and slightly induced by salt stress. Subcellular localization reveals that PtrLEA7 protein was located in both cytoplasm and nucleus. To investigate its function, transgenic plants of both tobacco and Poncirus trifoliata overexpressing PtrLEA7 were obtained. Stress tolerance assays show that overexpression lines had enhanced dehydration and drought tolerance compared with wild type plants, indicating that PtrLEA7 positively regulates drought tolerance. In addition, transgenic plants had much higher expression levels of three antioxidant enzyme genes (CAT, SOD and POD) and significantly increased catalase enzyme activity, accompanied by reduced reactive oxygen species accumulation in comparison with wild type plants. Collectively, this study demonstrates that PtrLEA7 can confer enhanced drought tolerance partially via enhancing antioxidant capacity.

 

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Development and testing of a weather-based model to determine potential yield losses caused by potato late

Alexey FILIPPOV, Maria KUZNETSOVA, Alexander ROGOZHIN, Olga IAKUSHEVA, Valentina DEMIDOVA, Natalia STATSYUK

《农业科学与工程前沿（英文）》 2018年 第5卷 第4期   页码 462-468 doi: 10.15302/J-FASE-2018239

摘要：

Late blight is one of the most important potato diseases. To minimize yield losses, various protective measures are used including fungicide application. Active use of fungicides results in a contamination of the environment. Therefore, crop protection strategies optimizing the number of treatments are of great interest. Using information about late blight development in an experimental potato field recorded over 30 seasons, a simulator to forecast yield losses caused by the disease was developed based on the number of 5-d periods favorable for reinfection of plants during a vegetation season. The simulator was successfully verified using independent data on the disease development from nine unprotected potato fields in the Netherlands and Germany. The average difference between the calculated and real yield losses did not exceed 5%. Using the simulator and weather data for a period of 2007-2017, yield losses were calculated for several areas of the Bryansk, Tambov, and Orenburg Regions of Russia. The results revealed differences in disease development between these regions and may be used to develop recommendations for a frequency of fungicide applications according to the regional risk of epidemics, leading to a significant reduction in fungicide use.

关键词： potato     late blight     Phytophthora infestans     yield losses     retrospective analysis     mathematical model    

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功能影像检测食管癌放疗过程中再增殖和乏氧以及预测临床疗效研究

于金明

《中国工程科学》 2012年 第14卷 第7期   页码 9-19

摘要：

18F-FLT PET能监测食管鳞癌放疗过程中肿瘤和正常组织的生物学变化，其较18F-FDG PET能较好区分炎症和肿瘤，能检测食管肿瘤放疗过程中的加速再增殖,18F-FETNIM PET能检测食管鳞癌的乏氧状态,18F-FLT PET和18F-FETNIM PET作为一种非创伤性的影像学技术，能为肿瘤医生提供一个早期评价治疗反应，检测放疗过程中的再增殖克隆源细胞、乏氧和评价新辅助治疗疗效的手段。18F-FLT PET和18F-FETNIM PET能为放射治疗确定“再增殖”和“乏氧”生物学靶区，以通过剂量调强放疗提高再增殖和乏氧区域放疗剂量，提高肿瘤的局部控制率和远期生存。

关键词： 食管肿瘤     放射疗法     正电子发射型     再增殖     乏氧    

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OVEREXPRESSION OF

Tonglu WEI, Dalong GUO, Jihong LIU

《农业科学与工程前沿（英文）》   页码 236-246 doi: 10.15302/J-FASE-2020368

摘要： Late embryogenesis abundant (LEA) genes encode highly hydrophilic proteins that are essential in abiotic stress responses. However, most LEA genes in higher plants have not yet been investigated. This study identified an LEA family gene (PtrLEA7) from Poncirus trifoliata and studied its function in drought tolerance. The full-length coding sequence of PtrLEA7 was 420 bp encoding a protein of 139 amino acids. Phylogenetic analysis shows that PtrLEA7 protein belongs to the LEA_4 subfamily. Expression profiling by qPCR found that PtrLEA7 was strongly induced by dehydration, cold and ABA treatments, and slightly induced by salt stress. Subcellular localization reveals that PtrLEA7 protein was located in both cytoplasm and nucleus. To investigate its function, transgenic plants of both tobacco and Poncirus trifoliata overexpressing PtrLEA7 were obtained. Stress tolerance assays show that overexpression lines had enhanced dehydration and drought tolerance compared with wild type plants, indicating that PtrLEA7 positively regulates drought tolerance. In addition, transgenic plants had much higher expression levels of three antioxidant enzyme genes (CAT, SOD and POD) and significantly increased catalase enzyme activity, accompanied by reduced reactive oxygen species accumulation in comparison with wild type plants. Collectively, this study demonstrates that PtrLEA7 can confer enhanced drought tolerance partially via enhancing antioxidant capacity.

关键词： abiotic stress     antioxidant     drought     late embryogenesis abundant     Poncirus trifoliata    

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Improved local control without elective nodal radiotherapy in patients with unresectable NSCLC treated

YANG Kunyu, LIU Li, ZHANG Tao, WU Gang, CAO Fengjun, WANG Jianhua

《医学前沿（英文）》 2007年 第1卷 第4期   页码 381-385 doi: 10.1007/s11684-007-0074-7

摘要： To investigate the influence of prophylactic elective nodal irradiation on the therapeutic results of definitive radiotherapy for patients with stage IIIA or stage IIIB unresectable non-small-cell lung cancer, 55 patients with clinically inoperable advanced non-small-cell lung cancer were studied. After four cycles of induction chemotherapy, the patients were divided into two groups at random. In one group, the elective nodal irradiation was included in clinical tumor volume (CTV) of definitive radiotherapy (ENI group); and in the other group, elective nodal irradiation was not included in CTV (non-ENI group). For the patients in the ENI group, the mean prescription dose for gross tumor volumes was 58.4 Gy, while for the patients in the non-ENI group, it was 65.8 Gy (<0.05). The responsive rates were 45.8% and 74.0% (<0.05), and the rate of the elective nodal failure (ENF) was 4.2% and 11.1%, respectively. Kaplan-Meier analysis showed that the mean local-progression-free survival time was 11.0 and 15.0 months, and one-year local-failure rates were 51.9% and 24.5% (<0.05). The median overall survival time was 13.0 and 15.0 months, respectively ( = 0.084). The one-year survival rates were 55.7% and 72.5%, and two-year survival rates were 0% and 19.9%. There was no significant difference in the occurrences of radiation-associated complications between the two groups. Our results showed that omitting elective nodal irradiation did not result in a high incidence of elective nodal failure. On the contrary, it decreased local failure by increasing prescription doses to the primary diseases and lymphadenopaphy, and thereby it may further prolong the patients survival.

关键词： significant difference     irradiation     unresectable non-small-cell     induction chemotherapy     influence    

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中国庐山地区大校场晚第四纪沉积年龄测定及层序地层学

胡东生,胡蓉,李小豫,胡文瑄,王旭龙,田新红,刘卫国,张国伟

《中国工程科学》 2012年 第14卷 第11期   页码 36-43

摘要：

通过庐山科学考察(1997—2009)对大校场沟口晚第四纪剖面地层进行精细研究，采用古地磁、电子自旋共振(ESR)、36Cl、释光法等多种仪器测年方法的分析，建立了完整剖面的全时段地层的自400 ka.B.P.以来的系列年龄数据，与之相对应识别出Biwa-III(320 ka.B.P.)事件、Biwa-II(260 ka.B.P.)事件、Biwa-I(180 ka.B.P.)事件（因铁盘扰动影响缺失）、Blake(100 ka.B.P.)事件、Laschamp(20 ka.B.P.)事件（因表层活动影响未发育）等古地磁极性事件，结合层序地层和层型特征及沉积环境将剖面地层由早至晚划分为4个发展旋回阶段：I阶段为冰期（400~200 ka.B.P.）气候时期，II阶段为间冰期（200~100 ka.B.P.）气候时期，III阶段为冰缘期（100~10 ka.B.P.）气候时期，IV阶段为冰后期（10~0 ka.B.P.）气候时期。

关键词： 晚第四纪沉积     多种器测定年数据     层型序列及综合年龄     沉积旋回阶段     庐山大校场    

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Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1376-0

摘要：

•Annual mean PM2.5 in Shijiazhuang were 87, 95, and 82 µg/m3 in 2015–2017.

关键词： PM2.5     Health effects     Integrated exposure-response model     Shijiazhuang    

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Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial

《医学前沿（英文）》 2023年 第17卷 第2期   页码 231-239 doi: 10.1007/s11684-022-0939-9

摘要： To evaluate the safety and efficacy of neoadjuvant radiohormonal therapy for oligometastatic prostate cancer (OMPC), we conducted a 3 + 3 dose escalation, prospective, phase I/II, single-arm clinical trial (CHiCTR1900025743), in which long-term neoadjuvant androgen deprivation was adopted 1 month before radiotherapy, comprising intensity modulated radiotherapy to the pelvis, and stereotactic body radiation therapy to all extra-pelvic bone metastases for 4‒7 weeks, at 39.6, 45, 50.4, and 54 Gy. Robotic-assisted radical prostatectomy was performed after 5‒14 weeks. The primary outcome was treatment-related toxicities and adverse events; secondary outcomes were radiological treatment response, positive surgical margin (pSM), postoperative prostate-specific antigen (PSA), pathological down-grading and tumor regression grade, and survival parameters. Twelve patients were recruited from March 2019 to February 2020, aging 66.2 years in average (range, 52‒80). Median baseline PSA was 62.0 ng/mL. All underwent RARP successfully without open conversions. Ten patients recorded pathological tumor down-staging (83.3%), and 5 (41.7%) with cN1 recorded negative regional lymph nodes on final pathology. 66.7% (8/12) recorded tumor regression grading (TRG) –I and 25% (3/12) recorded TRG-II. Median follow-up was 16.5 months. Mean radiological progression-free survival (RPFS) was 21.3 months, with 2-year RPFS of 83.3%. In all, neoadjuvant radiohormonal therapy is well tolerated for oligometastatic prostate cancer.

关键词： neoadjuvant     radiotherapy     oligometastatic     prostate cancer     radical prostatectomy    

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Polymerization of methyl methacrylate catalyzed by mono-/bis-salicylaldiminato nickel(II) complexes and methylaluminoxane

Jihong LU, Danfeng ZHANG, Qian CHEN, Buwei YU

《化学科学与工程前沿（英文）》 2011年 第5卷 第1期   页码 19-25 doi: 10.1007/s11705-010-0546-1

摘要： Two types of salicylaldiminato-based nickel complexes, mono-ligated Ni(II) complexes ([O-C H - - C(H)=N-Ar]Ni(PPh )(Ph) ( ), [O-(3,5-Br )C H - -C(H)=N-Ar]Ni(PPh )(Ph) ( ), [O-(3- -Bu)C H - -C(H)=N-Ar]Ni(PPh )(Ph) ( )) and bis-ligated Ni(II) complexes ([O-(3,5-Br )C H - -C(H)=N-Ar] Ni ( ), [O-(3,5-Br )C H - -C(H)=N-2-C H (PhO)] Ni ( ), Ar=2,6-C H ( -Pr) ) were synthesized and characterized by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), mass spectrography (MS) and elemental analysis (EA). In the presence of methylaluminoxane (MAO) as cocatalyst, all the nickel complexes exhibited high activities for the polymerization of methyl methacrylate (MMA) and syndiotactic-rich poly(methyl methacrylate) (PMMA) was obtained. The complexes with less bulky substituents on salicylaldiminato framework possessed higher activities, while with the same salicylaldiminato, the mono-ligated nickel complexes showed higher catalytic activity than bis-ligated ones.

关键词： late transition metal catalyst     methyl methacrylate     polymerization     salicylaldiminato nickel complexes     methylaluminoxane     syndiotactic structure    

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Synergistic effects of sodium hypochlorite disinfection and iron-oxidizing bacteria on early corrosion

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-021-1506-3

摘要：

• The early corrosion process in the cast iron pipes was investigated.

关键词： Cast iron pipe corrosion     Drinking water distribution systems     Chlorine disinfection     Iron-oxidizing bacteria     Coupling effects    

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Investigation of effects of Cocamide Diethanolamide chemical on physical and rheological properties of

《结构与土木工程前沿（英文）》 2022年 第16卷 第1期   页码 99-116 doi: 10.1007/s11709-021-0799-4

摘要： In this study, bituminous binder was modified with Cocamide Diethanolamide chemical, a non-ionic surfactant, and the physical and rheological properties of modified binders were investigated. In addition, Cocamide Diethanolamide has been used for the first time to modify bituminous binder, and this situation makes the study distinctive. Bituminous binder was modified more than once with the chemical by changing modification parameters and using certain additive ratios (1%, 3%, and 5%). The effects of different modification parameters and chemical additive on modified samples were investigated with conventional bitumen tests (softening point, penetration, ductility) and Superpave tests (rotational viscometer, rolling thin film oven test, pressure aging vessel, dynamic shear rheometer, bending beam rheometer). In addition, the structural characteristics of the reference binder and modified samples were examined by X-ray diffraction, Fourier Transform Infrared Spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. The examinations showed that Cocamide Diethanolamide softens bituminous binder and lowers processing temperatures. In addition, compared to reference binder, rutting resistances of modified bituminous binders decreased with the increase of additive ratio. However, modification with Cocamide Diethanolamide increased the resistance to fatigue cracks and thermal cracks.

关键词： Cocamide Diethanolamide     bitumen modification     rheology     Superpave tests    

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Protective effects of lignin fractions obtained from grape seeds against bisphenol AF neurotoxicity viaantioxidative effects mediated by the Nrf2 pathway

《化学科学与工程前沿（英文）》 2023年 第17卷 第7期   页码 976-989 doi: 10.1007/s11705-022-2237-0

摘要： Lignin exhibits antioxidative and various other biological properties. However, its neuroprotection capability has rarely been studied. In this study, three types of lignin with different structures were prepared from grape seeds by using different isolation techniques. The antioxidative and neuroprotective effects of the lignin fractions were evaluated with the apoptosis model of murine neuroectodermal (NE-4C) neural stem cells stimulated with bisphenol AF. The results demonstrated that the half maximal inhibitory concentration for scavenging 2,2-diphenyl-1-picrylhydrazyl with water-soluble lignin (L-W, 58.19 μg·mL–1) was lower than those of lignin in the autohydrolyzed residue of grape seeds (84.27 μg·mL–1) and original lignin in grape seeds (99.44 μg·mL–1). BPAF exposure had negative effects on the reactive oxygen species, malondialdehyde content, and superoxide dismutase and glutathione peroxidase activities in NE-4C cells, which can be reversed by using the prepared lignin to reduce oxidative stress. An immunofluorescence assay demonstrated that grape seed lignin induced protective effects on BPAF-injured NE-4C cells via the nuclear factor erythroid 2-related Factor 2 pathway. In addition, correlational analyses showed that lignin (L-W) with lower molecular weights and noncondensed phenolic hydroxyl group content and higher contents of COOH groups effectively prevented cell apoptosis, scavenged reactive oxygen species, and ensured protection from nerve injury. This study demonstrated that grape seed lignin can be used as a neuroprotective agent and serves as a demonstration of active lignin production from grape seed waste.

关键词： grape seed lignin     structure     antioxidant     NE-4C cells     neuroprotection    

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Quorum sensing regulation methods and their effects on biofilm in biological waste treatment systems:

《环境科学与工程前沿（英文）》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1495-2

摘要：

• Quorum sensing enhancement and inhibition methods are summarized.

关键词： Quorum sensing     Biological waste treatment     Biofilm formation    

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标题 作者 时间 类型 操作

Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

期刊论文

Artificial intelligence in radiotherapy: a technological review

Ke Sheng

期刊论文

OVEREXPRESSION OF PTRLEA7, A LATE EMBRYOGENESIS ABUNDANT FAMILY GENE FROM PONCIRUS TRIFOLIATA, CONFERS

期刊论文

Development and testing of a weather-based model to determine potential yield losses caused by potato late

Alexey FILIPPOV, Maria KUZNETSOVA, Alexander ROGOZHIN, Olga IAKUSHEVA, Valentina DEMIDOVA, Natalia STATSYUK

期刊论文

功能影像检测食管癌放疗过程中再增殖和乏氧以及预测临床疗效研究

于金明

期刊论文

OVEREXPRESSION OF

Tonglu WEI, Dalong GUO, Jihong LIU

期刊论文

Improved local control without elective nodal radiotherapy in patients with unresectable NSCLC treated

YANG Kunyu, LIU Li, ZHANG Tao, WU Gang, CAO Fengjun, WANG Jianhua

期刊论文

中国庐山地区大校场晚第四纪沉积年龄测定及层序地层学

胡东生,胡蓉,李小豫,胡文瑄,王旭龙,田新红,刘卫国,张国伟

期刊论文

Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

期刊论文

Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes from an open-label, dose-escalation, single-center, phase I/II clinical trial

期刊论文

Polymerization of methyl methacrylate catalyzed by mono-/bis-salicylaldiminato nickel(II) complexes and methylaluminoxane

Jihong LU, Danfeng ZHANG, Qian CHEN, Buwei YU

期刊论文

Synergistic effects of sodium hypochlorite disinfection and iron-oxidizing bacteria on early corrosion

期刊论文

Investigation of effects of Cocamide Diethanolamide chemical on physical and rheological properties of

期刊论文

Protective effects of lignin fractions obtained from grape seeds against bisphenol AF neurotoxicity viaantioxidative effects mediated by the Nrf2 pathway

期刊论文

Quorum sensing regulation methods and their effects on biofilm in biological waste treatment systems:

期刊论文